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Cancer Therapy · Transplantation

Hematopoietic Stem Cell Transplantation · Safer, Lower-Relapse, Higher Long-Term Survival

Transplantation is the most important platform for achieving long-term disease-free survival — and, for many hematologic diseases, cure. GHG delivers personalized transplant therapy with whole-process risk control: from pre-transplant evaluation and donor matching to conditioning, infusion, complication management and multi-year follow-up.

Steps in the hematopoietic stem cell transplantation process at GHG
4,000+
Transplants performed
1 month → 75 yrs
Age range treated
>79%
1-year overall survival
85%
Salvage HSCT share (single centre)

The Transplant Process

Success depends on depth of disease control, donor selection, conditioning intensity, infection control, GVHD management and long-term relapse monitoring.

01

Pre-Transplant Evaluation

Disease status, MRD, organ function, infection risk, prior treatment and physical status assessment.

02

Donor Matching & Stem-Cell Collection

Select an appropriate donor; collect stem cells and complete quality and safety assessment.

03

Pre-Transplant Conditioning

Chemotherapy / radiotherapy / immunosuppression to eliminate residual disease and create conditions for engraftment.

04

Stem-Cell Infusion

Healthy hematopoietic stem cells are infused, initiating hematopoiesis and immune reconstitution.

05

Inpatient Monitoring & Complication Management

Monitoring and supportive care for engraftment, infection, bleeding, organ toxicity and GVHD.

06

Recovery & Long-Term Follow-Up

Long-term management of MRD, chimerism, immune reconstitution, infection, GVHD and relapse.

Sterile HEPA-filtered isolation ward for hematopoietic stem cell transplant patients
Protected Environment

HEPA-Filtered Laminar Flow Wards

During the neutropenic phase after conditioning, patients recover inside positive-pressure laminar-flow rooms with continuous air filtration, dedicated staff and strict infection-control protocols — the foundation for safe engraftment.

From 1 Month to 75 Years · A High-Success Centre for All Ages

GHG's HSCT centres in Beijing, Shanghai and Guangzhou have pioneered multiple innovative transplant strategies and performed over 4,000 transplants — most in patients with relapsed or refractory disease. One-year overall survival exceeds 79%, establishing GHG as one of the most effective transplant centres in China.

The core clinical challenge — balancing the graft-versus-leukemia (GVL) effect against graft-versus-host disease (GVHD) — is met with personalized conditioning, donor selection, T-cell depletion/modulation, infection prevention and dynamic monitoring of chimerism and MRD.

GHG transplant patients from 1 month to 75 years old

GHG Distinctive Strengths

Eight signature transplant programmes with world-leading published outcomes.

GHG hematopoietic stem cell transplantation strengths and distinctive features
01

CAR-T Bridged to Allogeneic HSCT for Leukemia

Rapid disease control before transplant, deeper MRD clearance, dual immunologic attack and lower relapse risk. For R/R B-ALL patients achieving MRD-negativity after CAR-T, 1-year OS 84.8% and DFS 77.8%. For R/R T-ALL/LBL, 2-year OS 54.4% and DFS 51.0%.

02

Autologous HSCT Combined with CAR-T for Lymphoma

Dual-mechanism tumor clearance and prolonged remission. For R/R B-cell lymphoma: 1/2/3-year PFS 76.6% / 72.3% / 64.7%; OS 91.5% / 73.9% / 66.0%. For R/R CNS lymphoma, PFS not reached vs. 31.2 months control.

03

TDH Transplantation for Thalassemia & Benign Hematologic Disorders

GHG achieved the world's first GVHD-free / TM-free survival (GTFS) rate above 80% with TDH for thalassemia — 97.1% successful engraftment, OS 96.5%, TFS 94.3%. Triple protocol (CAR-T + UCB + TDH) reaches OS and DFS of 96% for R/R ALL across all age groups.

04

Second Allogeneic HSCT for Relapsed Leukemia & Lymphoma

For patients undergoing a second transplant: 1-year DFS 72.5%, OS 80.6%, non-relapse mortality only 2.3% — significantly exceeding international benchmarks.

05

HSCT for Elderly Patients

Age barriers pushed to 76 years old through personalized risk assessment, reduced-intensity conditioning and diverse donor options.

06

Salvage HSCT for Refractory Leukemia

Salvage HSCT represents 85% of all transplant cases at GHG's single centre, achieving a success rate of up to 50% — the only potentially curative option for long-term disease-free survival.

07

HSCT for R/R Peripheral T-Cell Lymphoma

Modified ATG-containing conditioning and individualized strategy: 2-year OS approaches 70%, versus historical 20–30%.

08

HSCT for Myelofibrosis

Prof. Chun WANG's team achieved 5-year survival improvement and a 60% cure rate with modified conditioning and individualized strategies.

Hematopoietic stem cells under fluorescence microscopy
CD34+ hematopoietic stem cells — the seed population that reconstitutes the entire blood and immune system after transplant.
Bag of hematopoietic stem cells prepared for infusion
Cryopreserved stem-cell product ready for infusion — each unit is quality-tested for viability, cell dose and microbial safety before release.

Conditions Treated with HSCT

At GHG, stem-cell transplantation benefits both cancerous and non-cancerous diseases.

Family-Centred Care

From First Consultation to Long-Term Follow-Up

Paediatric and adult patients recover with a dedicated multidisciplinary team — hematologists, transplant coordinators, infection-control specialists and psychologists — supporting the whole family through engraftment, discharge and years of monitoring.

Family visiting a young patient recovering after stem cell transplant
GHG National Science and Technology Progress Award and Chinese Medical Science and Technology Award

National Recognition & World-Firsts

  • Second Prize · National Science and Technology Progress Award — Prof. Chun WANG's team, for establishing allogeneic HSCT as salvage therapy for refractory malignant hematologic diseases.
  • NF-08-TM protocol (2008) — Prof. Chunfu LI's team was the world's first non-related donor transplant approach to achieve a cure rate over 90% in thalassemia (global benchmark then: 50%). Long-term OS 94.7%, TFS 93.3%.
  • CAR-T bridged to allo-HSCT for R/R B-ALL (2019) — GHG-first in China: 1-year OS 87.7%, LFS 73.0%, non-relapse mortality only 2.2%.
  • World's first HSCT for Lysinuric Protein Intolerance (LPI) — bringing hope to families with rare paediatric disease.

Free Case Feasibility Assessment

Start your medical journey to China

Based in Hong Kong and serving international patients, Privilege Medical bridges you to leading Class 3A and JCI-accredited hospitals in mainland China. We do not provide medical care directly — we coordinate specialist matching, medical visa support and on-the-ground concierge from your first enquiry to post-treatment follow-up.

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